› 1hpt

X-ray diffraction
2.3Å resolution

THREE-DIMENSIONAL STRUCTURE OF A RECOMBINANT VARIANT OF HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL TYPE)

Released:
DOI: 10.2210/pdb1hpt/pdb
PDB entry 1hpt coloured by chain, front view.
PDB entry 1hpt coloured by chain, side view.
PDB entry 1hpt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Three-dimensional structure of a recombinant variant of human pancreatic secretory trypsin inhibitor (Kazal type).
Hecht HJ, Szardenings M, Collins J, Schomburg D
J Mol Biol 225 1095-103 (1992)
PMID: 1613792

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133770 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine protease inhibitor Kazal-type 1 Chain: A
Molecule details ›
Chain: A
Length: 56 amino acids
Theoretical weight: 6.35 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00995 (Residues: 24-79; Coverage: 100%)
Gene names: PSTI, SPINK1
Sequence domains: Kazal-type serine protease inhibitor domain
Structure domains: Wheat Germ Agglutinin (Isolectin 2); domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P43
Unit cell:
a: 40.15Å b: 40.15Å c: 33.91Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.191 not available
Expression system: Not provided

Quick links

Citations

2 review citations

Common structural motifs in small proteins and domains.
Efimov AV. (1994)
1 more

27 mentions without citation

Protein-protein docking with a reduced protein model accounting for side-chain flexibility.
Zacharias M. (2003)
26 more