› 1hnc

X-ray diffraction
3Å resolution

CRYSTAL STRUCTURE OF HUMAN CLASS MU GLUTATHIONE TRANSFERASE GSTM2-2: EFFECTS OF LATTICE PACKING ON CONFORMATIONAL HETEROGENEITY

Released:
DOI: 10.2210/pdb1hnc/pdb
PDB entry 1hnc coloured by chain, front view.
PDB entry 1hnc coloured by chain, side view.
PDB entry 1hnc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human class mu glutathione transferase GSTM2-2. Effects of lattice packing on conformational heterogeneity.
Raghunathan S, Chandross RJ, Kretsinger RH, Allison TJ, Penington CJ, Rule GS
J Mol Biol 238 815-32 (1994)
PMID: 8182750

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151172 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase Mu 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 217 amino acids
Theoretical weight: 25.61 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P28161 (Residues: 2-218; Coverage: 100%)
Gene names: GST4, GSTM2
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand GDN 4 x GDN
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 56.936Å b: 79.67Å c: 220.071Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.25 0.25 not available
Expression system: Not provided

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Citations

7 review citations

Glutathione transferases, regulators of cellular metabolism and physiology.
Board et al. (2013)
6 more