Function and Biology

STRUCTURE OF BOVINE BETA-ACTIN-PROFILIN COMPLEX WITH ACTIN BOUND ATP PHOSPHATES SOLVENT ACCESSIBLE

Source organism: Bos taurus
Biochemical function: actin binding
Biological process: regulation of actin filament organization
Cellular component: cytoskeleton

Sequence families

Pfam Protein families (Pfam)
PF00235
Domain description: Profilin
Occurring in:
  1. Profilin-1
The deposited structure of PDB entry 1hlu contains 1 copy of Pfam domain PF00235 (Profilin) in Profilin-1. Showing 1 copy in chain B [auth P].

PF00022
Domain description: Actin
Occurring in:
  1. Actin, cytoplasmic 1
The deposited structure of PDB entry 1hlu contains 1 copy of Pfam domain PF00022 (Actin) in Actin, cytoplasmic 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004000
Domain description: Actin family
Occurring in:
  1. Actin, cytoplasmic 1
IPR005454
Domain description: Profilin1/2/3, vertebrate
Occurring in:
  1. Profilin-1
IPR005455
Domain description: Profilin, eukaryotic type
Occurring in:
  1. Profilin-1
IPR004001
Domain description: Actin, conserved site
Occurring in:
  1. Actin, cytoplasmic 1
IPR043129
Domain description: ATPase, nucleotide binding domain
Occurring in:
  1. Actin, cytoplasmic 1
IPR036140
Domain description: Profilin superfamily
Occurring in:
  1. Profilin-1
IPR027310
Domain description: Profilin conserved site
Occurring in:
  1. Profilin-1
IPR020902
Domain description: Actin/actin-like conserved site
Occurring in:
  1. Actin, cytoplasmic 1

Structure domains

CATH CATH domains
3.30.420.40
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Nucleotidyltransferase; domain 5
Occurring in:
  1. Actin, cytoplasmic 1
The deposited structure of PDB entry 1hlu contains 2 copies of CATH domain 3.30.420.40 (Nucleotidyltransferase; domain 5) in Actin, cytoplasmic 1. Showing 2 copies in chain A.
3.30.450.30
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Beta-Lactamase
Homology: Dynein light chain 2a, cytoplasmic
Occurring in:
  1. Profilin-1
The deposited structure of PDB entry 1hlu contains 1 copy of CATH domain 3.30.450.30 (Beta-Lactamase) in Profilin-1. Showing 1 copy in chain B [auth P].
3.90.640.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Actin; Chain A, domain 4
Homology: Actin; Chain A, domain 4
Occurring in:
  1. Actin, cytoplasmic 1
The deposited structure of PDB entry 1hlu contains 1 copy of CATH domain 3.90.640.10 (Actin; Chain A, domain 4) in Actin, cytoplasmic 1. Showing 1 copy in chain A.
SCOP SCOP annotations
53068
Class: Alpha and beta proteins (a/b)
Fold: Ribonuclease H-like motif
Superfamily: Actin-like ATPase domain
Occurring in:
  1. Actin, cytoplasmic 1
The deposited structure of PDB entry 1hlu contains 2 copies of SCOP domain 53068 (Actin/HSP70) in Actin, cytoplasmic 1. Showing 2 copies in chain A.
55771
Class: Alpha and beta proteins (a+b)
Fold: Profilin-like
Superfamily: Profilin (actin-binding protein)
Occurring in:
  1. Profilin-1
The deposited structure of PDB entry 1hlu contains 1 copy of SCOP domain 55771 (Profilin (actin-binding protein)) in Profilin-1. Showing 1 copy in chain B [auth P].