Structure analysis

Receptor binding redefined by a structural switch in a mutant Human Insulin

Solution NMR
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 4070.85 Å2
Buried surface area: 1022.34 Å2
Dissociation area: 511.17 Å2
Dissociation energy (ΔGdiss): 8.13 kcal/mol
Dissociation entropy (TΔSdiss): 8.01 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134182
Complex Portal ID: CPX-943

Macromolecules

Chain: A
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
InterPro:
SCOP: Insulin-like

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Chain: B
Length: 30 amino acids
Theoretical weight: 3.34 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS
Pfam: Insulin/IGF/Relaxin family
InterPro:
SCOP: Insulin-like

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