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INTERLEUKIN-4 (WILD-TYPE)

X-ray diffraction
2.6Å resolution
PDB entry 1hik coloured by chain, front view.
PDB entry 1hik coloured by chain, side view.
PDB entry 1hik coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Interleukin-4
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Multimeric state: homo dimer
Accessible surface area: 12583.47 Å2
Buried surface area: 1595.59 Å2
Dissociation area: 797.79 Å2
Dissociation energy (ΔGdiss): -5.24 kcal/mol
Dissociation entropy (TΔSdiss): 11.67 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138516

Macromolecules

Interleukin-4
Chain: A
Length: 129 amino acids
Theoretical weight: 14.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05112 (Residues: 25-153; Coverage: 100%)
Gene name: IL4
Pfam: Interleukin 4
InterPro:
CATH: Growth Hormone; Chain: A;
SCOP: Short-chain cytokines
Interleukin-4 in PDB entry 1hik, assembly 1, front view.
Interleukin-4 in PDB entry 1hik, assembly 1, side view.
Interleukin-4 in PDB entry 1hik, assembly 1, top view.
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