Structure analysis

BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY

X-ray diffraction
2.7Å resolution
Assembly composition:
hetero hexamer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero hexamer
Accessible surface area: 57500 Å2
Buried surface area: 42400 Å2
Dissociation area: 8,100 Å2
Dissociation energy (ΔGdiss): 40 kcal/mol
Dissociation entropy (TΔSdiss): 33 kcal/mol
Interface energy (ΔGint): -83 kcal/mol
Symmetry number: 3

Macromolecules

Chains: A, C, E
Length: 328 amino acids
Theoretical weight: 36.07 KDa
Source organism: Influenza A virus (A/X-31(H3N2))
Expression system: Not provided
UniProt:
  • Canonical: P03438 (Residues: 17-344; Coverage: 60%)
Gene name: HA
InterPro:
CATH: Hemagglutinin (Ha1 Chain); Chain: A; domain 1
SCOP: Influenza hemagglutinin headpiece

Search similar proteins

Chains: B, D, F
Length: 175 amino acids
Theoretical weight: 20.21 KDa
Source organism: Influenza A virus (A/X-31(H3N2))
Expression system: Not provided
UniProt:
  • Canonical: P03438 (Residues: 346-520; Coverage: 32%)
Gene name: HA
InterPro:
CATH: Hemagglutinin Ectodomain; Chain B
SCOP: Influenza hemagglutinin (stalk)

Search similar proteins