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BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY

X-ray diffraction
2.7Å resolution
PDB 1hgh coloured by chain and viewed from the front.
PDB 1hgh coloured by chain and viewed from the side.
PDB 1hgh coloured by chain and viewed from the top.
Source organism: Influenza A virus (A/X-31(H3N2))
Assembly composition:
hetero hexamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 57500 Å2
Buried surface area: 42400 Å2
Dissociation area: 8,100 Å2
Dissociation energy (ΔGdiss): 40 kcal/mol
Dissociation entropy (TΔSdiss): 33 kcal/mol
Interface energy (ΔGint): -83 kcal/mol
Symmetry number: 3

Macromolecules

Hemagglutinin HA1 chain
Chains: A, C, E
Length: 328 amino acids
Theoretical weight: 36.07 KDa
Source organism: Influenza A virus (A/X-31(H3N2))
Expression system: Not provided
UniProt:
  • Canonical: P03438 (Residues: 17-344; Coverage: 60%)
Gene name: HA
InterPro:
CATH: Hemagglutinin (Ha1 Chain); Chain: A; domain 1
SCOP: Influenza hemagglutinin headpiece
PDB 1hgh contains 3 copies of Hemagglutinin HA1 chain in assembly 1. This protein is highlighted and viewed from the front.
PDB 1hgh contains 3 copies of Hemagglutinin HA1 chain in assembly 1. This protein is highlighted and viewed from the side.
PDB 1hgh contains 3 copies of Hemagglutinin HA1 chain in assembly 1. This protein is highlighted and viewed from the top.
Molecule details ›

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Hemagglutinin HA2 chain
Chains: B, D, F
Length: 175 amino acids
Theoretical weight: 20.21 KDa
Source organism: Influenza A virus (A/X-31(H3N2))
Expression system: Not provided
UniProt:
  • Canonical: P03438 (Residues: 346-520; Coverage: 32%)
Gene name: HA
InterPro:
CATH: Hemagglutinin Ectodomain; Chain B
SCOP: Influenza hemagglutinin (stalk)
PDB 1hgh contains 3 copies of Hemagglutinin HA2 chain in assembly 1. This protein is highlighted and viewed from the front.
PDB 1hgh contains 3 copies of Hemagglutinin HA2 chain in assembly 1. This protein is highlighted and viewed from the side.
PDB 1hgh contains 3 copies of Hemagglutinin HA2 chain in assembly 1. This protein is highlighted and viewed from the top.
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