› 1hgg

X-ray diffraction
2.9Å resolution

BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY

Released:
DOI: 10.2210/pdb1hgg/pdb
PDB 1hgg coloured by chain and viewed from the front.
PDB 1hgg coloured by chain and viewed from the side.
PDB 1hgg coloured by chain and viewed from the top.
Source organism: Influenza A virus (A/X-31(H3N2))
Primary publication:
Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.
Sauter NK, Hanson JE, Glick GD, Brown JH, Crowther RL, Park SJ, Skehel JJ, Wiley DC
Biochemistry 31 9609-21 (1992)
PMID: 1327122

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
Non-polymer only hexamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Hemagglutinin HA1 chain Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 328 amino acids
Theoretical weight: 36.07 KDa
Source organism: Influenza A virus (A/X-31(H3N2))
Expression system: Not provided
UniProt:
  • Canonical: P03437 (Residues: 17-344; Coverage: 60%)
Gene name: HA
Structure domains: Hemagglutinin (Ha1 Chain); Chain: A; domain 1
Hemagglutinin HA2 chain Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 175 amino acids
Theoretical weight: 20.21 KDa
Source organism: Influenza A virus (A/X-31(H3N2))
Expression system: Not provided
UniProt:
  • Canonical: P03437 (Residues: 346-520; Coverage: 32%)
Gene name: HA
Structure domains: Hemagglutinin Ectodomain; Chain B

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Ligand NAG 6 x NAG
Ligand BMA 3 x BMA
Carbohydrate polymer : NEW Components: BGC, GAL, SIA
Ligand BGC 6 x BGC
Ligand GAL 6 x GAL
Ligand SIA 6 x SIA
1 bound ligand:
Ligand NAG 12 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P41
Unit cell:
a: 162.7Å b: 162.7Å c: 177.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.229 not available
Expression system: Not provided

Quick links

Citations

31 review citations

Structural Insights for Anti-Influenza Vaccine Design.
Han et al. (2019)
30 more

25 mentions without citation

The sweet spot: defining virus-sialic acid interactions.
Stencel-Baerenwald et al. (2014)
24 more