PDBe 1hfd

X-ray diffraction
2.3Å resolution

Function and Biology Details

Reaction catalysed:
Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
COMPLEMENT FACTOR D Chain: A
Molecule details ›
Chain: A
Length: 228 amino acids
Theoretical weight: 24.44 KDa
Source organism: Homo sapiens
Structure domains: Trypsin-like serine proteases

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P21
Unit cell:
a: 55.71Å b: 51.15Å c: 39.47Å
α: 90° β: 105.96° γ: 90°
R-values:
R R work R free
0.174 0.174 0.216