Structure analysis

STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN AT 2.6 ANGSTROMS RESOLUTION FROM MAD ANALYSIS OF THE SELENOMETHIONYL PROTEIN

X-ray diffraction
2.6Å resolution
Source organism: Homo sapiens
Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 11000 Å2
Buried surface area: 4600 Å2
Dissociation area: 2,000 Å2
Dissociation energy (ΔGdiss): 20 kcal/mol
Dissociation entropy (TΔSdiss): 12 kcal/mol
Interface energy (ΔGint): -11 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: hetero tetramer
Accessible surface area: 19800 Å2
Buried surface area: 11400 Å2
Dissociation area: 1,200 Å2
Dissociation energy (ΔGdiss): 15 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -45 kcal/mol
Symmetry number: 2

Macromolecules

Chain: A
Length: 92 amino acids
Theoretical weight: 10.22 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01215 (Residues: 25-116; Coverage: 100%)
Gene name: CGA
InterPro:
CATH: Cystine-knot cytokines
SCOP: Gonadodropin/Follitropin

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Chain: B
Length: 145 amino acids
Theoretical weight: 15.55 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P0DN86 (Residues: 21-165; Coverage: 100%)
Gene names: CGB, CGB3, CGB5, CGB8
Pfam: Cystine-knot domain
InterPro:
CATH: Cystine-knot cytokines
SCOP: Gonadodropin/Follitropin

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