PDBe 1hcn

X-ray diffraction
2.6Å resolution

STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN AT 2.6 ANGSTROMS RESOLUTION FROM MAD ANALYSIS OF THE SELENOMETHIONYL PROTEIN

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glycoprotein hormones alpha chain Chain: A
Molecule details ›
Chain: A
Length: 92 amino acids
Theoretical weight: 10.22 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01215 (Residues: 25-116; Coverage: 100%)
Gene name: CGA
Structure domains: Cystine-knot cytokines
Choriogonadotropin subunit beta 3 Chain: B
Molecule details ›
Chain: B
Length: 145 amino acids
Theoretical weight: 15.55 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P0DN86 (Residues: 21-165; Coverage: 100%)
Gene names: CGB, CGB3, CGB5, CGB8
Sequence domains: Cystine-knot domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P6522
Unit cell:
a: 85.1Å b: 85.1Å c: 177.7Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.199 not available
Expression system: Not provided