1hcg

X-ray diffraction
2.2Å resolution

STRUCTURE OF HUMAN DES(1-45) FACTOR XA AT 2.2 ANGSTROMS RESOLUTION

Released:

Function and Biology Details

Reaction catalysed:
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Activated factor Xa heavy chain Chain: A
Molecule details ›
Chain: A
Length: 241 amino acids
Theoretical weight: 27.2 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00742 (Residues: 235-475; Coverage: 53%)
Gene name: F10
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Factor X light chain Chain: B
Molecule details ›
Chain: B
Length: 51 amino acids
Theoretical weight: 5.5 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00742 (Residues: 129-179; Coverage: 11%)
Gene name: F10
Structure domains: Laminin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P41212
Unit cell:
a: 93.66Å b: 93.66Å c: 119.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 not available not available
Expression system: Not provided