› 1hab

X-ray diffraction
2.3Å resolution

CROSSLINKED HAEMOGLOBIN

Released:
DOI: 10.2210/pdb1hab/pdb
PDB entry 1hab coloured by chain, front view.
PDB entry 1hab coloured by chain, side view.
PDB entry 1hab coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Allosteric intermediates indicate R2 is the liganded hemoglobin end state.
Schumacher MA, Zheleznova EE, Poundstone KS, Kluger R, Jones RT, Brennan RG
Proc Natl Acad Sci U S A 94 7841-4 (1997)
PMID: 9223274

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159519 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hemoglobin subunit alpha Chains: A, C
Molecule details ›
Chains: A, C
Length: 141 amino acids
Theoretical weight: 15.15 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P69905 (Residues: 2-142; Coverage: 99%)
Gene names: HBA1, HBA2
Sequence domains: Globin
Structure domains: Globins
Hemoglobin subunit beta Chains: B, D
Molecule details ›
Chains: B, D
Length: 146 amino acids
Theoretical weight: 15.89 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P68871 (Residues: 2-147; Coverage: 99%)
Gene name: HBB
Sequence domains: Globin
Structure domains: Globins

Ligands and Environments

3 bound ligands:
Ligand HEM 4 x HEM
Ligand CMO 4 x CMO
Ligand CIN 1 x CIN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P212121
Unit cell:
a: 86.84Å b: 87.11Å c: 97.63Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.191 not available

Quick links

Citations

4 review citations

Molecular aspects of embryonic hemoglobin function.
Brittain T. (2002)
3 more

2 mentions without citation

Calmodulin: A Multitasking Protein in Kv7.2 Potassium Channel Functions.
Alaimo et al. (2018)
1 more