Function and Biology

Solution structure of the 49 aa presequence of 5-ALAS

Source organism: Mus musculus
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

EC 2.3.1.37: 5-aminolevulinate synthase

Reaction catalysed:
Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2)
Systematic name:
Succinyl-CoA:glycine C-succinyltransferase (decarboxylating)
Alternative Name(s):
  • 5-aminolevulinate synthetase
  • 5-aminolevulinic acid synthase
  • 5-aminolevulinic acid synthetase
  • ALA synthase
  • ALA synthetase
  • ALAS
  • Alpha-aminolevulinic acid synthase
  • Aminolevulinate synthase
  • Aminolevulinate synthetase
  • Aminolevulinic acid synthase
  • Aminolevulinic acid synthetase
  • Aminolevulinic synthetase
  • Delta-ALA synthetase
  • Delta-aminolevulinate synthase
  • Delta-aminolevulinate synthetase
  • Delta-aminolevulinic acid synthase
  • Delta-aminolevulinic acid synthetase
  • Delta-aminolevulinic synthetase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF09029
Domain description: 5-aminolevulinate synthase presequence
Occurring in:
  1. 5-aminolevulinate synthase, erythroid-specific, mitochondrial

Structure domain

CATH CATH domain
4.10.92.10
Class: Few Secondary Structures
Architecture: Irregular
Topology: Aminolevulinic Acid Synthase 2
Homology: Aminolevulinic Acid Synthase 2
Occurring in:
  1. 5-aminolevulinate synthase, erythroid-specific, mitochondrial
The deposited structure of PDB entry 1h7d contains 1 copy of CATH domain 4.10.92.10 (Aminolevulinic Acid Synthase 2) in 5-aminolevulinate synthase, erythroid-specific, mitochondrial. Showing 1 copy in chain A.
SCOP SCOP annotation
70029
Class: Peptides
Fold: Prepeptide of 5-ALAS
Superfamily: Prepeptide of 5-ALAS
Occurring in:
  1. 5-aminolevulinate synthase, erythroid-specific, mitochondrial
The deposited structure of PDB entry 1h7d contains 1 copy of SCOP domain 70029 (Prepeptide of 5-ALAS) in 5-aminolevulinate synthase, erythroid-specific, mitochondrial. Showing 1 copy in chain A.