1h6f

X-ray diffraction
1.7Å resolution

Human TBX3, a transcription factor responsible for ulnar-mammary syndrome, bound to a palindromic DNA site

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
T-box transcription factor TBX3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 193 amino acids
Theoretical weight: 22.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15119 (Residues: 99-311; Coverage: 26%)
  • Best match: O15119-2 (Residues: 99-291)
Gene name: TBX3
Sequence domains: T-box
Structure domains: Transcription factor, T-box
5'-D(*TP*AP*AP*TP*TP*TP*CP*AP*CP*AP*CP*CP*TP* AP*GP*GP*TP*GP*TP*GP*AP*AP*AP*T)-3' Chains: C, D
Molecule details ›
Chains: C, D
Length: 24 nucleotides
Theoretical weight: 7.37 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID13
Spacegroup: P212121
Unit cell:
a: 39.04Å b: 104.91Å c: 125.31Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.201 0.239
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided