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Monoclinic form of human peroxiredoxin 5

Source organism: Homo sapiens
Biochemical function: oxidoreductase activity
Biological process: cellular response to oxidative stress
Cellular component: not assigned

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EC 1.11.1.24: Thioredoxin-dependent peroxiredoxin

Reaction catalysed:
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Systematic name:
Thioredoxin:hydroperoxide oxidoreductase
Alternative Name(s):
  • Thioredoxin peroxidase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF08534
Domain description: Redoxin
Occurring in:
  1. Peroxiredoxin-5, mitochondrial
The deposited structure of PDB entry 1h4o contains 8 copies of Pfam domain PF08534 (Redoxin) in Peroxiredoxin-5, mitochondrial. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR037944
Domain description: Peroxiredoxin-5-like
Occurring in:
  1. Peroxiredoxin-5, mitochondrial
IPR013740
Domain description: Redoxin
Occurring in:
  1. Peroxiredoxin-5, mitochondrial
IPR013766
Domain description: Thioredoxin domain
Occurring in:
  1. Peroxiredoxin-5, mitochondrial
IPR036249
Domain description: Thioredoxin-like superfamily
Occurring in:
  1. Peroxiredoxin-5, mitochondrial

Structure domain

CATH CATH domain
3.40.30.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Glutaredoxin
Homology: Glutaredoxin
Occurring in:
  1. Peroxiredoxin-5, mitochondrial
The deposited structure of PDB entry 1h4o contains 8 copies of CATH domain 3.40.30.10 (Glutaredoxin) in Peroxiredoxin-5, mitochondrial. Showing 1 copy in chain A.
SCOP SCOP annotation
52901
Class: Alpha and beta proteins (a/b)
Fold: Thioredoxin fold
Superfamily: Thioredoxin-like
Occurring in:
  1. Peroxiredoxin-5, mitochondrial
The deposited structure of PDB entry 1h4o contains 8 copies of SCOP domain 52901 (Glutathione peroxidase-like) in Peroxiredoxin-5, mitochondrial. Showing 1 copy in chain A.

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