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Anthocyanidin synthase from Arabidopsis thaliana complexed with trans-dihydroquercetin (with 30 min exposure to O2)

Source organism: Arabidopsis thaliana
Biochemical function: dioxygenase activity
Biological process: proanthocyanidin biosynthetic process
Cellular component: not assigned

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EC 1.14.20.4: Anthocyanidin synthase

Reaction catalysed:
(1a) a (2R,3S,4S)-leucoanthocyanidin + 2-oxoglutarate + O(2) = a (4S)- 2,3-dehydroflavan-3,4-diol + succinate + CO(2) + H(2)O
Systematic name:
(2R,3S,4S)-leucoanthocyanidin,2-oxoglutarate:oxygen oxidoreductase
Alternative Name(s):
  • ANS (gene name)
  • Leucoanthocyanidin dioxygenase
  • Leucocyanidin oxygenase
  • Leucocyanidin,2-oxoglutarate:oxygen oxidoreductase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF03171
Domain description: 2OG-Fe(II) oxygenase superfamily
Occurring in:
  1. Leucoanthocyanidin dioxygenase
The deposited structure of PDB entry 1gp6 contains 1 copy of Pfam domain PF03171 (2OG-Fe(II) oxygenase superfamily) in Leucoanthocyanidin dioxygenase. Showing 1 copy in chain A.

PF14226
Domain description: non-haem dioxygenase in morphine synthesis N-terminal
Occurring in:
  1. Leucoanthocyanidin dioxygenase
The deposited structure of PDB entry 1gp6 contains 1 copy of Pfam domain PF14226 (non-haem dioxygenase in morphine synthesis N-terminal) in Leucoanthocyanidin dioxygenase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR044861
Domain description: Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain
Occurring in:
  1. Leucoanthocyanidin dioxygenase
IPR005123
Domain description: Oxoglutarate/iron-dependent dioxygenase
Occurring in:
  1. Leucoanthocyanidin dioxygenase
IPR026992
Domain description: Non-haem dioxygenase N-terminal domain
Occurring in:
  1. Leucoanthocyanidin dioxygenase
IPR027443
Domain description: Isopenicillin N synthase-like superfamily
Occurring in:
  1. Leucoanthocyanidin dioxygenase

Structure domain

CATH CATH domain
2.60.120.330
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: B-lactam Antibiotic, Isopenicillin N Synthase; Chain
Occurring in:
  1. Leucoanthocyanidin dioxygenase
The deposited structure of PDB entry 1gp6 contains 1 copy of CATH domain 2.60.120.330 (Jelly Rolls) in Leucoanthocyanidin dioxygenase. Showing 1 copy in chain A.
SCOP SCOP annotation
51198
Class: All beta proteins
Fold: Double-stranded beta-helix
Superfamily: Clavaminate synthase-like
Occurring in:
  1. Leucoanthocyanidin dioxygenase
The deposited structure of PDB entry 1gp6 contains 1 copy of SCOP domain 51198 (Penicillin synthase-like) in Leucoanthocyanidin dioxygenase. Showing 1 copy in chain A.

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