EC 2.7.7.6: DNA-directed RNA polymerase
Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
Alternative Name(s):
- C RNA formation factors
- C ribonucleic acid formation factors
- DNA-dependent RNA nucleotidyltransferase
- DNA-dependent RNA polymerase
- DNA-dependent ribonucleate nucleotidyltransferase
- Deoxyribonucleic acid-dependent ribonucleic acid polymerase
- RNA nucleotidyltransferase
- RNA nucleotidyltransferase (DNA-directed)
- RNA polymerase
- RNA polymerase I
- RNA polymerase II
- RNA polymerase III
- RNA transcriptase
- Ribonucleate nucleotidyltransferase
- Ribonucleate polymerase
- Ribonucleic acid nucleotidyltransferase
- Ribonucleic acid polymerase
- Ribonucleic acid transcriptase
- Ribonucleic polymerase
- Ribonucleic transcriptase
- Transcriptase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 1go3 contains 2 copies of Pfam domain PF03874 (RNA polymerase Rpb4) in DNA-directed RNA polymerase subunit Rpo4. Showing 1 copy in chain B [auth F].](https://www.ebi.ac.uk/pdbe/static/entry/1go3_2_F_Pfam_PF03874_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1go3</span> contains 2 copies of Pfam domain <span class='highlight'>PF03874 (RNA polymerase Rpb4)</span> in <span class='highlight'>DNA-directed RNA polymerase subunit Rpo4</span>. Showing 1 copy in chain <span class='highlight'>B [auth F]</span>.")
![The deposited structure of PDB entry 1go3 contains 2 copies of Pfam domain PF00575 (S1 RNA binding domain) in DNA-directed RNA polymerase subunit Rpo7. Showing 1 copy in chain A [auth E].](https://www.ebi.ac.uk/pdbe/static/entry/1go3_1_E_Pfam_PF00575_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1go3</span> contains 2 copies of Pfam domain <span class='highlight'>PF00575 (S1 RNA binding domain)</span> in <span class='highlight'>DNA-directed RNA polymerase subunit Rpo7</span>. Showing 1 copy in chain <span class='highlight'>A [auth E]</span>.")
![The deposited structure of PDB entry 1go3 contains 2 copies of Pfam domain PF03876 (SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397) in DNA-directed RNA polymerase subunit Rpo7. Showing 1 copy in chain A [auth E].](https://www.ebi.ac.uk/pdbe/static/entry/1go3_1_E_Pfam_PF03876_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1go3</span> contains 2 copies of Pfam domain <span class='highlight'>PF03876 (SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397)</span> in <span class='highlight'>DNA-directed RNA polymerase subunit Rpo7</span>. Showing 1 copy in chain <span class='highlight'>A [auth E]</span>.")
InterPro annotations
Structure domains
CATH domains
1.10.150.80
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
DNA polymerase; domain 1
Homology:
HRDC domain
Occurring in:
![The deposited structure of PDB entry 1go3 contains 2 copies of CATH domain 1.10.150.80 (DNA polymerase; domain 1) in DNA-directed RNA polymerase subunit Rpo4. Showing 1 copy in chain B [auth F].](https://www.ebi.ac.uk/pdbe/static/entry/1go3_2_F_CATH_1.10.150.80_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1go3</span> contains 2 copies of CATH domain <span class='highlight'>1.10.150.80 (DNA polymerase; domain 1)</span> in <span class='highlight'>DNA-directed RNA polymerase subunit Rpo4</span>. Showing 1 copy in chain <span class='highlight'>B [auth F]</span>.")
6.10.140.10
Class:
Special
Architecture:
Helix non-globular
Topology:
Helix Hairpins
Homology:
Helix Hairpins
Occurring in:
![The deposited structure of PDB entry 1go3 contains 2 copies of CATH domain 6.10.140.10 (Helix Hairpins) in DNA-directed RNA polymerase subunit Rpo4. Showing 1 copy in chain B [auth F].](https://www.ebi.ac.uk/pdbe/static/entry/1go3_2_F_CATH_6.10.140.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1go3</span> contains 2 copies of CATH domain <span class='highlight'>6.10.140.10 (Helix Hairpins)</span> in <span class='highlight'>DNA-directed RNA polymerase subunit Rpo4</span>. Showing 1 copy in chain <span class='highlight'>B [auth F]</span>.")
2.40.50.140
Class:
Mainly Beta
Architecture:
Beta Barrel
Topology:
OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology:
Nucleic acid-binding proteins
Occurring in:
![The deposited structure of PDB entry 1go3 contains 2 copies of CATH domain 2.40.50.140 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in DNA-directed RNA polymerase subunit Rpo7. Showing 1 copy in chain A [auth E].](https://www.ebi.ac.uk/pdbe/static/entry/1go3_1_E_CATH_2.40.50.140_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1go3</span> contains 2 copies of CATH domain <span class='highlight'>2.40.50.140 (OB fold (Dihydrolipoamide Acetyltransferase, E2P))</span> in <span class='highlight'>DNA-directed RNA polymerase subunit Rpo7</span>. Showing 1 copy in chain <span class='highlight'>A [auth E]</span>.")
![The deposited structure of PDB entry 1go3 contains 2 copies of CATH domain 3.30.1490.120 (Dna Ligase; domain 1) in DNA-directed RNA polymerase subunit Rpo7. Showing 1 copy in chain A [auth E].](https://www.ebi.ac.uk/pdbe/static/entry/1go3_1_E_CATH_3.30.1490.120_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1go3</span> contains 2 copies of CATH domain <span class='highlight'>3.30.1490.120 (Dna Ligase; domain 1)</span> in <span class='highlight'>DNA-directed RNA polymerase subunit Rpo7</span>. Showing 1 copy in chain <span class='highlight'>A [auth E]</span>.")
SCOP annotations
![The deposited structure of PDB entry 1go3 contains 2 copies of SCOP domain 69044 (RNA polymerase II subunit RBP4 (RpoF)) in DNA-directed RNA polymerase subunit Rpo4. Showing 1 copy in chain B [auth F].](https://www.ebi.ac.uk/pdbe/static/entry/1go3_2_F_SCOP_69044_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1go3</span> contains 2 copies of SCOP domain <span class='highlight'>69044 (RNA polymerase II subunit RBP4 (RpoF))</span> in <span class='highlight'>DNA-directed RNA polymerase subunit Rpo4</span>. Showing 1 copy in chain <span class='highlight'>B [auth F]</span>.")
50282
Class:
All beta proteins
Fold:
OB-fold
Superfamily:
Nucleic acid-binding proteins
Occurring in:
![The deposited structure of PDB entry 1go3 contains 2 copies of SCOP domain 50282 (Cold shock DNA-binding domain-like) in DNA-directed RNA polymerase subunit Rpo7. Showing 1 copy in chain A [auth E].](https://www.ebi.ac.uk/pdbe/static/entry/1go3_1_E_SCOP_50282_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1go3</span> contains 2 copies of SCOP domain <span class='highlight'>50282 (Cold shock DNA-binding domain-like)</span> in <span class='highlight'>DNA-directed RNA polymerase subunit Rpo7</span>. Showing 1 copy in chain <span class='highlight'>A [auth E]</span>.")
88799
Class:
Alpha and beta proteins (a+b)
Fold:
Dodecin subunit-like
Superfamily:
N-terminal, heterodimerisation domain of RBP7 (RpoE)
Occurring in:
![The deposited structure of PDB entry 1go3 contains 2 copies of SCOP domain 88799 (N-terminal, heterodimerisation domain of RBP7 (RpoE)) in DNA-directed RNA polymerase subunit Rpo7. Showing 1 copy in chain A [auth E].](https://www.ebi.ac.uk/pdbe/static/entry/1go3_1_E_SCOP_88799_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1go3</span> contains 2 copies of SCOP domain <span class='highlight'>88799 (N-terminal, heterodimerisation domain of RBP7 (RpoE))</span> in <span class='highlight'>DNA-directed RNA polymerase subunit Rpo7</span>. Showing 1 copy in chain <span class='highlight'>A [auth E]</span>.")