› 1gih

X-ray diffraction
2.8Å resolution

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR

Released:
DOI: 10.2210/pdb1gih/pdb
PDB 1gih coloured by chain and viewed from the front.
PDB 1gih coloured by chain and viewed from the side.
PDB 1gih coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Crystallographic approach to identification of cyclin-dependent kinase 4 (CDK4)-specific inhibitors by using CDK4 mimic CDK2 protein.
Ikuta M, Kamata K, Fukasawa K, Honma T, Machida T, Hirai H, Suzuki-Takahashi I, Hayama T, Nishimura S
J. Biol. Chem. 276 27548-54 (2001)
PMID: 11335721

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 33.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 1PU 1 x 1PU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 73.87Å b: 72.67Å c: 53.85Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.169 0.275
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

Pharmacological targeting of CDK9 in cardiac hypertrophy.
Krystof et al. (2010)
4 more

3 mentions without citation

Prediction of calcium-binding sites by combining loop-modeling with machine learning.
Liu et al. (2009)
2 more