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RETINOBLASTOMA POCKET COMPLEXED WITH SV40 LARGE T ANTIGEN

X-ray diffraction
3.2Å resolution
PDB entry 1gh6 coloured by chain, front view.
PDB entry 1gh6 coloured by chain, side view.
PDB entry 1gh6 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Large T antigen and Retinoblastoma-associated protein
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Multimeric state: hetero dimer
Accessible surface area: 24296.28 Å2
Buried surface area: 1586.07 Å2
Dissociation area: 793.03 Å2
Dissociation energy (ΔGdiss): -1.26 kcal/mol
Dissociation entropy (TΔSdiss): 12.24 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136536

Macromolecules

Large T antigen
Chain: A
Length: 114 amino acids
Theoretical weight: 13.44 KDa
Source organism: Betapolyomavirus macacae
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P03070 (Residues: 7-117; Coverage: 16%)
InterPro:
CATH: DnaJ domain
SCOP: Chaperone J-domain
Large T antigen in PDB entry 1gh6, assembly 1, front view.
Large T antigen in PDB entry 1gh6, assembly 1, side view.
Large T antigen in PDB entry 1gh6, assembly 1, top view.
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Retinoblastoma-associated protein
Chain: B
Length: 333 amino acids
Theoretical weight: 39.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P06400 (Residues: 379-577, 645-772; Coverage: 35%)
Gene name: RB1
Pfam:
InterPro:
CATH: Cyclin-like
SCOP: Retinoblastoma tumor suppressor domains
Retinoblastoma-associated protein in PDB entry 1gh6, assembly 1, front view.
Retinoblastoma-associated protein in PDB entry 1gh6, assembly 1, side view.
Retinoblastoma-associated protein in PDB entry 1gh6, assembly 1, top view.
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