› 1g5j

Solution NMR

COMPLEX OF BCL-XL WITH PEPTIDE FROM BAD

Released:
DOI: 10.2210/pdb1g5j/pdb
PDB entry 1g5j coloured by chain, front view.
PDB entry 1g5j coloured by chain, side view.
PDB entry 1g5j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies.
Petros AM, Nettesheim DG, Wang Y, Olejniczak ET, Meadows RP, Mack J, Swift K, Matayoshi ED, Zhang H, Thompson CB, Fesik SW
Protein Sci 9 2528-34 (2000)
PMID: 11206074

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170522 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bcl-2-like protein 1 Chain: A
Molecule details ›
Chain: A
Length: 175 amino acids
Theoretical weight: 19.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07817 (Residues: 1-209; Coverage: 73%)
Gene names: BCL2L, BCL2L1, BCLX
Sequence domains:
Structure domains: Blc2-like
Bcl2-associated agonist of cell death Chain: B
Molecule details ›
Chain: B
Length: 25 amino acids
Theoretical weight: 3.11 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q92934 (Residues: 103-126; Coverage: 14%)
Gene names: BAD, BBC6, BCL2L8

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

64 review citations

The BCL-2 protein family: opposing activities that mediate cell death.
Youle et al. (2008)
63 more

36 mentions without citation

Classification of intrinsically disordered regions and proteins.
van der Lee et al. (2014)
35 more