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CRYSTAL STRUCTURE OF THE H. INFLUENZAE PROTEASE HSLV AT 1.9 A RESOLUTION

Source organism: Haemophilus influenzae
Biochemical function: metal ion binding
Biological process: proteolysis involved in protein catabolic process
Cellular component: HslUV protease complex

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EC 3.4.25.2: HslU--HslV peptidase

Reaction catalysed:
ATP-dependent cleavage of peptide bonds with broad specificity.
Systematic name:
-
Alternative Name(s):
  • ATP-dependent HslV-HslU proteinase
  • Caseinolytic protease X
  • Caseinolytic proteinase X
  • ClpQ
  • ClpXP ATP-dependent protease
  • ClpXP protease
  • ClpXP serine proteinase
  • ClpYQ
  • ClpYQ protease
  • Escherichia coli ClpXP serine proteinase
  • HslUV
  • HslUV protease
  • HslUV proteinase
  • HslV peptidase
  • HslV-HslU
  • HslVU protease
  • HslVU proteinase
  • Protease ClpYQ
  • Protease CodWX
  • Protease HslVU
  • Proteinase ClpYQ
  • Proteinase HslUV

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00227
Domain description: Proteasome subunit
Occurring in:
  1. ATP-dependent protease subunit HslV
The deposited structure of PDB entry 1g3k contains 3 copies of Pfam domain PF00227 (Proteasome subunit) in ATP-dependent protease subunit HslV. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029055
Domain description: Nucleophile aminohydrolases, N-terminal
Occurring in:
  1. ATP-dependent protease subunit HslV
IPR023333
Domain description: Proteasome B-type subunit
Occurring in:
  1. ATP-dependent protease subunit HslV
IPR022281
Domain description: ATP-dependent protease, HslV subunit
Occurring in:
  1. ATP-dependent protease subunit HslV
IPR001353
Domain description: Proteasome, subunit alpha/beta
Occurring in:
  1. ATP-dependent protease subunit HslV

Structure domain

CATH CATH domain
3.60.20.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homology: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Occurring in:
  1. ATP-dependent protease subunit HslV
The deposited structure of PDB entry 1g3k contains 3 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in ATP-dependent protease subunit HslV. Showing 1 copy in chain A.
SCOP SCOP annotation
56251
Class: Alpha and beta proteins (a+b)
Fold: Ntn hydrolase-like
Superfamily: N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Occurring in:
  1. ATP-dependent protease subunit HslV
The deposited structure of PDB entry 1g3k contains 3 copies of SCOP domain 56251 (Proteasome subunits) in ATP-dependent protease subunit HslV. Showing 1 copy in chain A.

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