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THE CRYSTAL STRUCTURE OF THE E.COLI ADP-RIBOSE PYROPHOSPHATASE

Source organism: Escherichia coli
Biochemical function: ADP-ribose diphosphatase activity
Biological process: ribose phosphate metabolic process
Cellular component: cytosol

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EC 3.6.1.13: ADP-ribose diphosphatase

Reaction catalysed:
ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphate
Systematic name:
ADP-D-ribose ribophosphohydrolase
Alternative Name(s):
  • ADP-ribose phosphohydrolase
  • ADP-ribose pyrophosphatase
  • ADP-ribose ribophosphohydrolase
  • ADPR-PPase
  • ADPribose diphosphatase
  • ADPribose pyrophosphatase
  • Adenosine diphosphoribose pyrophosphatase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00293
Domain description: NUDIX domain
Occurring in:
  1. ADP-ribose pyrophosphatase
The deposited structure of PDB entry 1g0s contains 2 copies of Pfam domain PF00293 (NUDIX domain) in ADP-ribose pyrophosphatase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000086
Domain description: NUDIX hydrolase domain
Occurring in:
  1. ADP-ribose pyrophosphatase
IPR020084
Domain description: NUDIX hydrolase, conserved site
Occurring in:
  1. ADP-ribose pyrophosphatase
IPR004385
Domain description: Nucleoside diphosphate pyrophosphatase
Occurring in:
  1. ADP-ribose pyrophosphatase
IPR015797
Domain description: NUDIX hydrolase-like domain superfamily
Occurring in:
  1. ADP-ribose pyrophosphatase

Structure domain

CATH CATH domain
3.90.79.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Nucleoside Triphosphate Pyrophosphohydrolase
Homology: Nucleoside Triphosphate Pyrophosphohydrolase
Occurring in:
  1. ADP-ribose pyrophosphatase
The deposited structure of PDB entry 1g0s contains 2 copies of CATH domain 3.90.79.10 (Nucleoside Triphosphate Pyrophosphohydrolase) in ADP-ribose pyrophosphatase. Showing 1 copy in chain B.
SCOP SCOP annotation
55812
Class: Alpha and beta proteins (a+b)
Fold: Nudix
Superfamily: Nudix
Occurring in:
  1. ADP-ribose pyrophosphatase
The deposited structure of PDB entry 1g0s contains 2 copies of SCOP domain 55812 (MutT-like) in ADP-ribose pyrophosphatase. Showing 1 copy in chain B.

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