1fxl

X-ray diffraction
1.8Å resolution

CRYSTAL STRUCTURE OF HUD AND AU-RICH ELEMENT OF THE C-FOS RNA

Released:
Source organism: Homo sapiens
Primary publication:
Structural basis for recognition of AU-rich element RNA by the HuD protein.
Nat. Struct. Biol. 8 141-5 (2001)
PMID: 11175903

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
ELAV-like protein 4 Chain: A
Molecule details ›
Chain: A
Length: 167 amino acids
Theoretical weight: 18.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P26378 (Residues: 49-215; Coverage: 43%)
Gene names: ELAVL4, HUD, PNEM
Sequence domains: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Structure domains: Alpha-Beta Plaits
5'-R(P*UP*UP*UP*UP*AP*UP*UP*UP*U)-3' Chain: B
Molecule details ›
Chain: B
Length: 9 nucleotides
Theoretical weight: 2.73 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P21
Unit cell:
a: 30.31Å b: 99.38Å c: 33.34Å
α: 90° β: 106.4° γ: 90°
R-values:
R R work R free
0.193 0.192 0.239
Expression systems:
  • Escherichia coli
  • Not provided