› 1fvc

X-ray diffraction
2.2Å resolution

X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING

Released:
DOI: 10.2210/pdb1fvc/pdb
PDB entry 1fvc coloured by chain, front view.
PDB entry 1fvc coloured by chain, side view.
PDB entry 1fvc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
Eigenbrot C, Randal M, Presta L, Carter P, Kossiakoff AA
J Mol Biol 229 969-95 (1993)
PMID: 8095303

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213006 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
IGG1-KAPPA 4D5 FV (LIGHT CHAIN) Chains: A, C
Molecule details ›
Chains: A, C
Length: 109 amino acids
Theoretical weight: 11.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
IGG1-KAPPA 4D5 FV (HEAVY CHAIN) Chains: B, D
Molecule details ›
Chains: B, D
Length: 120 amino acids
Theoretical weight: 13.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 37.6Å b: 63.4Å c: 90.2Å
α: 90° β: 98.2° γ: 90°
R-values:
R R work R free
0.183 0.183 not available
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Anatomy of the antibody molecule.
Padlan EA. (1994)
10 more

33 mentions without citation

The Biological Structure Model Archive (BSM-Arc): an archive for in silico models and simulations.
Bekker et al. (2020)
32 more