› 1frb

X-ray diffraction
1.7Å resolution

FR-1 PROTEIN/NADPH/ZOPOLRESTAT COMPLEX

Released:
DOI: 10.2210/pdb1frb/pdb
PDB entry 1frb coloured by chain, front view.
PDB entry 1frb coloured by chain, side view.
PDB entry 1frb coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
1.7 A structure of FR-1, a fibroblast growth factor-induced member of the aldo-keto reductase family, complexed with coenzyme and inhibitor.
Wilson DK, Nakano T, Petrash JM, Quiocho FA
Biochemistry 34 14323-30 (1995)
PMID: 7578036

Function and Biology Details

Reaction catalysed: 
Alditol + NAD(P)(+) = aldose + NAD(P)H
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155275 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aldose reductase-related protein 2 Chain: A
Molecule details ›
Chain: A
Length: 315 amino acids
Theoretical weight: 36.04 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P45377 (Residues: 2-316; Coverage: 100%)
Gene names: Akr1b8, Fgfrp
Sequence domains: Aldo/keto reductase family
Structure domains: NADP-dependent oxidoreductase domain

Ligands and Environments


Cofactor: Ligand NDP 1 x NDP
1 bound ligand:
Ligand ZST 1 x ZST
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 59.45Å b: 65.38Å c: 90.29Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.158 0.158 not available
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Comparative anatomy of the aldo-keto reductase superfamily.
Jez et al. (1997)
4 more

5 mentions without citation

Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10.
Gallego et al. (2007)
4 more