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X-ray structure of a cyclic statine inhibitor PD-129,541 bound to yeast proteinase A

Source organism: Saccharomyces cerevisiae
Biochemical function: aspartic-type endopeptidase activity
Biological process: proteolysis
Cellular component: fungal-type vacuole

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EC 3.4.23.25: Saccharopepsin

Reaction catalysed:
Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu-|-Val-Tyr- bond in a synthetic substrate. Does not act on esters of Tyr or Arg.
Systematic name:
-
Alternative Name(s):
  • Aspartic proteinase yscA
  • PRA
  • Proteinase A
  • Proteinase yscA
  • Saccharomyces aspartic proteinase
  • Saccharomyces cerevisiae aspartic proteinase A
  • Yeast endopeptidase A
  • Yeast proteinase A

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00026
Domain description: Eukaryotic aspartyl protease
Occurring in:
  1. Saccharopepsin
The deposited structure of PDB entry 1fq5 contains 1 copy of Pfam domain PF00026 (Eukaryotic aspartyl protease) in Saccharopepsin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001461
Domain description: Aspartic peptidase A1 family
Occurring in:
  1. Saccharopepsin
IPR021109
Domain description: Aspartic peptidase domain superfamily
Occurring in:
  1. Saccharopepsin
IPR001969
Domain description: Aspartic peptidase, active site
Occurring in:
  1. Saccharopepsin
IPR033121
Domain description: Peptidase family A1 domain
Occurring in:
  1. Saccharopepsin
IPR033819
Domain description: Saccharopepsin
Occurring in:
  1. Saccharopepsin

Structure domain

CATH CATH domain
2.40.70.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Cathepsin D, subunit A; domain 1
Homology: Acid Proteases
Occurring in:
  1. Saccharopepsin
The deposited structure of PDB entry 1fq5 contains 2 copies of CATH domain 2.40.70.10 (Cathepsin D, subunit A; domain 1) in Saccharopepsin. Showing 2 copies in chain A.
SCOP SCOP annotation
50646
Class: All beta proteins
Fold: Acid proteases
Superfamily: Acid proteases
Occurring in:
  1. Saccharopepsin
The deposited structure of PDB entry 1fq5 contains 1 copy of SCOP domain 50646 (Pepsin-like) in Saccharopepsin. Showing 1 copy in chain A.

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