› 1fnf

X-ray diffraction
2Å resolution

FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10

Released:
DOI: 10.2210/pdb1fnf/pdb
PDB entry 1fnf coloured by chain, front view.
PDB entry 1fnf coloured by chain, side view.
PDB entry 1fnf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region.
Leahy DJ, Aukhil I, Erickson HP
Cell 84 155-64 (1996)
PMID: 8548820

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136132 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ugl-Y3 Chain: A
Molecule details ›
Chain: A
Length: 368 amino acids
Theoretical weight: 39.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02751 (Residues: 1173-1631; Coverage: 15%)
Gene names: FN, FN1
Sequence domains: Fibronectin type III domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21
Unit cell:
a: 64.05Å b: 60.67Å c: 58.44Å
α: 90° β: 103° γ: 90°
R-values:
R R work R free
0.216 0.216 0.308
Expression system: Escherichia coli

Quick links

Citations

69 review citations

Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering.
Zhu J. (2010)
68 more

98 mentions without citation

Characterization of the fast dynamics of protein amino acid side chains using NMR relaxation in solution.
Igumenova et al. (2006)
97 more