› › Structure analysis

HUMAN FOLLICLE STIMULATING HORMONE

X-ray diffraction
3Å resolution
PDB entry 1fl7 coloured by chain, front view.
PDB entry 1fl7 coloured by chain, side view.
PDB entry 1fl7 coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
hetero dimer
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1
Download    3D Visualisation
Assembly Name: Follicle-stimulating hormone complex
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 11905.21 Å2
Buried surface area: 5940.64 Å2
Dissociation area: 2,167.44 Å2
Dissociation energy (ΔGdiss): 33.63 kcal/mol
Dissociation entropy (TΔSdiss): 11.73 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134112
Complex Portal ID: CPX-665
Assembly 2
Download    3D Visualisation
Assembly Name: Follicle-stimulating hormone complex
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 11959.89 Å2
Buried surface area: 5610.42 Å2
Dissociation area: 2,012.18 Å2
Dissociation energy (ΔGdiss): 28.53 kcal/mol
Dissociation entropy (TΔSdiss): 11.7 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134112
Complex Portal ID: CPX-665
Assembly 3 (preferred)
Download    3D Visualisation
Assembly Name: Follitropin subunit beta and Glycoprotein hormones alpha chain
hide full assembly name
Multimeric state: hetero tetramer
Accessible surface area: 21422.88 Å2
Buried surface area: 13993.28 Å2
Dissociation area: 1,246.72 Å2
Dissociation energy (ΔGdiss): 8.67 kcal/mol
Dissociation entropy (TΔSdiss): 12.79 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134120

Macromolecules

Glycoprotein hormones alpha chain
Chains: A, C
Length: 92 amino acids
Theoretical weight: 10.22 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P01215 (Residues: 25-116; Coverage: 100%)
Gene name: CGA
Pfam: Glycoprotein hormone
InterPro:
CATH: Cystine-knot cytokines
SCOP: Gonadodropin/Follitropin
Glycoprotein hormones alpha chain in PDB entry 1fl7, assembly 3, front view.
Glycoprotein hormones alpha chain in PDB entry 1fl7, assembly 3, side view.
Glycoprotein hormones alpha chain in PDB entry 1fl7, assembly 3, top view.
Molecule details ›

Search similar proteins

Follitropin subunit beta
Chains: B, D
Length: 111 amino acids
Theoretical weight: 12.47 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P01225 (Residues: 19-129; Coverage: 100%)
Gene name: FSHB
Pfam: Cystine-knot domain
InterPro:
CATH: Cystine-knot cytokines
SCOP: Gonadodropin/Follitropin
Follitropin subunit beta in PDB entry 1fl7, assembly 3, front view.
Follitropin subunit beta in PDB entry 1fl7, assembly 3, side view.
Follitropin subunit beta in PDB entry 1fl7, assembly 3, top view.
Molecule details ›

Search similar proteins

Quick links