1fl7

X-ray diffraction
3Å resolution

HUMAN FOLLICLE STIMULATING HORMONE

Released:
Source organism: Homo sapiens
Primary publication:
Three-dimensional structure of human follicle-stimulating hormone.
Mol. Endocrinol. 15 378-89 (2001)
PMID: 11222739

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glycoprotein hormones alpha chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 92 amino acids
Theoretical weight: 10.22 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P01215 (Residues: 25-116; Coverage: 100%)
Gene name: CGA
Structure domains: Cystine-knot cytokines
Follitropin subunit beta Chains: B, D
Molecule details ›
Chains: B, D
Length: 111 amino acids
Theoretical weight: 12.47 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P01225 (Residues: 19-129; Coverage: 100%)
Gene name: FSHB
Structure domains: Cystine-knot cytokines

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P41212
Unit cell:
a: 128.3Å b: 128.3Å c: 155.22Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.259 0.259 0.294
Expression system: Spodoptera frugiperda