› 1fkz

Solution NMR

NMR STUDY OF B-DNA CONTAINING A MISMATCHED BASE PAIR IN THE 29-39 K-RAS GENE SEQUENCE: CC CT C+C C+T, 2 STRUCTURES

Released:
DOI: 10.2210/pdb1fkz/pdb
PDB entry 1fkz coloured by chain, ensemble of 2 models, front view.
PDB entry 1fkz coloured by chain, ensemble of 2 models, side view.
PDB entry 1fkz coloured by chain, ensemble of 2 models, top view.
Source organism: Synthetic construct
Primary publication:
Solution structure as a function of pH of two central mismatches, C . T and C . C, in the 29 to 39 K-ras gene sequence, by nuclear magnetic resonance and molecular dynamics.
Boulard Y, Cognet JA, Fazakerley GV
J Mol Biol 268 331-47 (1997)
PMID: 9159474

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113812 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
DNA (5'-D(*GP*CP*CP*AP*CP*CP*AP*GP*CP*TP*C)-3') Chain: A
Molecule details ›
Chain: A
Length: 11 nucleotides
Theoretical weight: 3.28 KDa
Source organism: Synthetic construct
Expression system: Not provided
DNA (5'-D(*GP*AP*GP*CP*TP*CP*GP*TP*GP*GP*C)-3') Chain: B
Molecule details ›
Chain: B
Length: 11 nucleotides
Theoretical weight: 3.39 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

2 review citations

Finding needles in a basestack: recognition of mismatched base pairs in DNA by small molecules.
Granzhan et al. (2014)
1 more

2 mentions without citation

The structural impact of DNA mismatches.
Rossetti et al. (2015)
1 more