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CRYSTAL STRUCTURE ANALYSIS OF O-SUCCINYLBENZOATE SYNTHASE FROM E. COLI

Source organism: Escherichia coli
Biochemical function: metal ion binding
Biological process: menaquinone biosynthetic process
Cellular component: not assigned

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EC 4.2.1.113: o-succinylbenzoate synthase

Reaction catalysed:
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H(2)O
Systematic name:
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate hydrolyase (2-succinylbenzoate-forming)
Alternative Name(s):
  • 2-succinylbenzoate synthase
  • MenC
  • OSB synthase
  • OSBS
  • o-succinylbenzoic acid synthase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF13378
Domain description: Enolase C-terminal domain-like
Occurring in:
  1. o-succinylbenzoate synthase
The deposited structure of PDB entry 1fhu contains 1 copy of Pfam domain PF13378 (Enolase C-terminal domain-like) in o-succinylbenzoate synthase. Showing 1 copy in chain A.

PF21508
Domain description: MenC, N-terminal domain
Occurring in:
  1. o-succinylbenzoate synthase
The deposited structure of PDB entry 1fhu contains 1 copy of Pfam domain PF21508 (MenC, N-terminal domain) in o-succinylbenzoate synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036849
Domain description: Enolase-like, C-terminal domain superfamily
Occurring in:
  1. o-succinylbenzoate synthase
IPR029017
Domain description: Enolase-like, N-terminal
Occurring in:
  1. o-succinylbenzoate synthase
IPR029065
Domain description: Enolase C-terminal domain-like
Occurring in:
  1. o-succinylbenzoate synthase
IPR013342
Domain description: Mandelate racemase/muconate lactonizing enzyme, C-terminal
Occurring in:
  1. o-succinylbenzoate synthase
IPR010196
Domain description: o-Succinylbenzoate synthase, MenC type1
Occurring in:
  1. o-succinylbenzoate synthase

Structure domains

CATH CATH domains
3.30.390.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Enolase-like; domain 1
Homology: Enolase-like, N-terminal domain
Occurring in:
  1. o-succinylbenzoate synthase
The deposited structure of PDB entry 1fhu contains 1 copy of CATH domain 3.30.390.10 (Enolase-like; domain 1) in o-succinylbenzoate synthase. Showing 1 copy in chain A.
3.20.20.120
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Enolase-like C-terminal domain
Occurring in:
  1. o-succinylbenzoate synthase
The deposited structure of PDB entry 1fhu contains 1 copy of CATH domain 3.20.20.120 (TIM Barrel) in o-succinylbenzoate synthase. Showing 1 copy in chain A.
SCOP SCOP annotations
51609
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: Enolase C-terminal domain-like
Occurring in:
  1. o-succinylbenzoate synthase
The deposited structure of PDB entry 1fhu contains 1 copy of SCOP domain 51609 (D-glucarate dehydratase-like) in o-succinylbenzoate synthase. Showing 1 copy in chain A.
54827
Class: Alpha and beta proteins (a+b)
Fold: Enolase N-terminal domain-like
Superfamily: Enolase N-terminal domain-like
Occurring in:
  1. o-succinylbenzoate synthase
The deposited structure of PDB entry 1fhu contains 1 copy of SCOP domain 54827 (Enolase N-terminal domain-like) in o-succinylbenzoate synthase. Showing 1 copy in chain A.

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