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CRYSTAL STRUCTURE OF ISOCITRATE LYASE:NITROPROPIONATE:GLYOXYLATE COMPLEX FROM MYCOBACTERIUM TUBERCULOSIS

X-ray diffraction
2.25Å resolution
PDB entry 1f8i coloured by chain, front view.
PDB entry 1f8i coloured by chain, side view.
PDB entry 1f8i coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Isocitrate lyase
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Multimeric state: homo tetramer
Accessible surface area: 48786.73 Å2
Buried surface area: 34790.66 Å2
Dissociation area: 6,229.09 Å2
Dissociation energy (ΔGdiss): 59.95 kcal/mol
Dissociation entropy (TΔSdiss): 16.78 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-161751

Macromolecules

Isocitrate lyase
Chains: A, B, C, D
Length: 429 amino acids
Theoretical weight: 47.19 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WKK7 (Residues: 2-428; Coverage: 100%)
Gene names: MTV038.11, Rv0467, icl
Pfam: Isocitrate lyase family
InterPro:
CATH: Phosphoenolpyruvate-binding domains
SCOP: Phosphoenolpyruvate mutase/Isocitrate lyase-like
Isocitrate lyase in PDB entry 1f8i, assembly 1, front view.
Isocitrate lyase in PDB entry 1f8i, assembly 1, side view.
Isocitrate lyase in PDB entry 1f8i, assembly 1, top view.
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