Structure analysis

CRYSTAL STRUCTURE OF MURINE GAMMA HERPESVIRUS CYCLIN COMPLEXED TO HUMAN CYCLIN DEPENDENT KINASE 2

X-ray diffraction
2.5Å resolution
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 24400 Å2
Buried surface area: 2700 Å2
Dissociation area: 1,300 Å2
Dissociation energy (ΔGdiss): 7 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -22 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: hetero dimer
Accessible surface area: 24400 Å2
Buried surface area: 2500 Å2
Dissociation area: 1,200 Å2
Dissociation energy (ΔGdiss): 4 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -10 kcal/mol
Symmetry number: 1

Macromolecules

Chains: A, C
Length: 298 amino acids
Theoretical weight: 33.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit

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Chains: B, D
Length: 252 amino acids
Theoretical weight: 29.07 KDa
Source organism: Murid gammaherpesvirus 4
Expression system: Escherichia coli
UniProt:
  • Canonical: P89883 (Residues: 1-252; Coverage: 100%)
Gene names: 72, GAMMAHV.ORF72, v-cyclin
Pfam: Cyclin, N-terminal domain
InterPro:
CATH: Cyclin-like
SCOP: Cyclin

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