Structure analysis

CRYSTAL STRUCTURE ANALYSIS OF PRECORRIN-8X METHYLMUTASE OF AEROBIC VITAMIN B12 SYNTHESIS

X-ray diffraction
2.1Å resolution
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 16300 Å2
Buried surface area: 3600 Å2
Dissociation area: 1,800 Å2
Dissociation energy (ΔGdiss): 24 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -26 kcal/mol
Symmetry number: 2

Macromolecules

Chain: A
Length: 219 amino acids
Theoretical weight: 23.22 KDa
Source organism: Pseudomonas denitrificans (nomen rejiciendum)
Expression system: Escherichia coli
UniProt:
  • Canonical: P21638 (Residues: 2-210; Coverage: 100%)
Gene name: cobH
Pfam: Precorrin-8X methylmutase
InterPro:
CATH: Cobalamin biosynthesis CobH/CbiC, precorrin-8X methylmutase
SCOP: Precorrin-8X methylmutase CbiC/CobH

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