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CRYSTAL STRUCTURE OF FGF1 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFR1)

X-ray diffraction
2.8Å resolution
PDB entry 1evt coloured by chain, front view.
PDB entry 1evt coloured by chain, side view.
PDB entry 1evt coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Fibroblast growth factor 1 and Fibroblast growth factor receptor 1
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Multimeric state: hetero tetramer
Accessible surface area: 29045.64 Å2
Buried surface area: 7467.1 Å2
Dissociation area: 3,333.72 Å2
Dissociation energy (ΔGdiss): 6.81 kcal/mol
Dissociation entropy (TΔSdiss): 38 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138609

Macromolecules

Fibroblast growth factor 1
Chains: A, B
Length: 134 amino acids
Theoretical weight: 15.23 KDa
Source organism: Homo sapiens
Expression system: Bacteria
UniProt:
  • Canonical: P05230 (Residues: 22-155; Coverage: 87%)
Gene names: FGF1, FGFA
Pfam: Fibroblast growth factor
InterPro:
CATH: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
SCOP: Fibroblast growth factors (FGF)
Fibroblast growth factor 1 in PDB entry 1evt, assembly 1, front view.
Fibroblast growth factor 1 in PDB entry 1evt, assembly 1, side view.
Fibroblast growth factor 1 in PDB entry 1evt, assembly 1, top view.
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Fibroblast growth factor receptor 1
Chains: C, D
Length: 225 amino acids
Theoretical weight: 25.26 KDa
Source organism: Homo sapiens
Expression system: Bacteria
UniProt:
  • Canonical: P11362 (Residues: 141-365; Coverage: 28%)
Gene names: BFGFR, CEK, FGFBR, FGFR1, FLG, FLT2, HBGFR
Pfam: Immunoglobulin I-set domain
InterPro:
CATH: Immunoglobulins
SCOP: I set domains
Fibroblast growth factor receptor 1 in PDB entry 1evt, assembly 1, front view.
Fibroblast growth factor receptor 1 in PDB entry 1evt, assembly 1, side view.
Fibroblast growth factor receptor 1 in PDB entry 1evt, assembly 1, top view.
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