1evt

X-ray diffraction
2.8Å resolution

CRYSTAL STRUCTURE OF FGF1 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFR1)

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fibroblast growth factor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 134 amino acids
Theoretical weight: 15.23 KDa
Source organism: Homo sapiens
Expression system: Bacteria
UniProt:
  • Canonical: P05230 (Residues: 22-155; Coverage: 87%)
Gene names: FGF1, FGFA
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Fibroblast growth factor receptor 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 225 amino acids
Theoretical weight: 25.26 KDa
Source organism: Homo sapiens
Expression system: Bacteria
UniProt:
  • Canonical: P11362 (Residues: 141-365; Coverage: 28%)
Gene names: BFGFR, CEK, FGFBR, FGFR1, FLG, FLT2, HBGFR
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P1
Unit cell:
a: 62.553Å b: 64.061Å c: 64.139Å
α: 93.4° β: 111.17° γ: 97.18°
R-values:
R R work R free
0.249 0.249 0.3
Expression system: Bacteria