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DIRECT STRUCTURE OBSERVATION OF AN ACYL-ENZYME INTERMEDIATE IN THE HYDROLYSIS OF AN ESTER SUBSTRATE BY ELASTASE

Source organism: Sus scrofa
Biochemical function: metal ion binding
Biological process: proteolysis
Cellular component: extracellular space

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EC 3.4.21.36: Pancreatic elastase

Reaction catalysed:
Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-.
Alternative Name(s):
  • Elastase
  • Elaszym
  • Pancreatic elastase I
  • Pancreatopeptidase E
  • Serine elastase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00089
Domain description: Trypsin
Occurring in:
  1. Chymotrypsin-like elastase family member 1
The deposited structure of PDB entry 1esa contains 1 copy of Pfam domain PF00089 (Trypsin) in Chymotrypsin-like elastase family member 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Chymotrypsin-like elastase family member 1
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Chymotrypsin-like elastase family member 1
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Chymotrypsin-like elastase family member 1
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Chymotrypsin-like elastase family member 1
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Chymotrypsin-like elastase family member 1
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Chymotrypsin-like elastase family member 1

Structure domain

CATH CATH domain
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Chymotrypsin-like elastase family member 1
The deposited structure of PDB entry 1esa contains 2 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Chymotrypsin-like elastase family member 1. Showing 2 copies in chain A.
SCOP SCOP annotation
50514
Class: All beta proteins
Fold: Trypsin-like serine proteases
Superfamily: Trypsin-like serine proteases
Occurring in:
  1. Chymotrypsin-like elastase family member 1
The deposited structure of PDB entry 1esa contains 1 copy of SCOP domain 50514 (Eukaryotic proteases) in Chymotrypsin-like elastase family member 1. Showing 1 copy in chain A.

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