› 1err

X-ray diffraction
2.6Å resolution

HUMAN ESTROGEN RECEPTOR LIGAND-BINDING DOMAIN IN COMPLEX WITH RALOXIFENE

Released:
DOI: 10.2210/pdb1err/pdb
PDB 1err coloured by chain and viewed from the front.
PDB 1err coloured by chain and viewed from the side.
PDB 1err coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Molecular basis of agonism and antagonism in the oestrogen receptor.
Brzozowski AM, Pike AC, Dauter Z, Hubbard RE, Bonn T, Engström O, Ohman L, Greene GL, Gustafsson JA, Carlquist M
Nature 389 753-8 (1997)
PMID: 9338790

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 253 amino acids
Theoretical weight: 28.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 301-553; Coverage: 43%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand RAL 2 x RAL
1 modified residue:
Ligand CCS 2 x CCS

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: C2
Unit cell:
a: 104.53Å b: 53.68Å c: 102.71Å
α: 90° β: 116.79° γ: 90°
R-values:
R R work R free
0.219 0.219 0.299
Expression system: Escherichia coli

Quick links

Citations

394 review citations

Estrogen deficiency - a central paradigm in age-related impaired healing?
El Mohtadi et al. (2021)
393 more

36 mentions without citation

The new biology of estrogen-induced apoptosis applied to treat and prevent breast cancer.
Jordan VC. (2015)
35 more