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SOLUTION STRUCTURE OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE COMPLEXED WITH MGAMPPCP

Source organism: Escherichia coli
Biochemical function: kinase activity
Biological process: folic acid biosynthetic process
Cellular component: not assigned

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EC 2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

Reaction catalysed:
ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate
Systematic name:
ATP:6-hydroxymethyl-7,8-dihydropterin 6'-diphosphotransferase
Alternative Name(s):
  • 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
  • 6-hydroxymethyl-7,8-dihydropterin diphosphokinase
  • 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
  • 7,8-dihydro-6-hydroxymethylpterin diphosphokinase
  • 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase
  • 7,8-dihydroxymethylpterin-pyrophosphokinase
  • ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase
  • H(2)-Pteridine-CH(2)OH pyrophosphokinase
  • HPPK
  • Hydroxymethyldihydropteridine pyrophosphokinase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01288
Domain description: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
Occurring in:
  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
The deposited structure of PDB entry 1eq0 contains 1 copy of Pfam domain PF01288 (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)) in 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000550
Domain description: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK
Occurring in:
  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IPR035907
Domain description: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK superfamily
Occurring in:
  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

Structure domain

CATH CATH domain
3.30.70.560
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK
Occurring in:
  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
The deposited structure of PDB entry 1eq0 contains 1 copy of CATH domain 3.30.70.560 (Alpha-Beta Plaits) in 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. Showing 1 copy in chain A.
SCOP SCOP annotation
55084
Class: Alpha and beta proteins (a+b)
Fold: Ferredoxin-like
Superfamily: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
Occurring in:
  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
The deposited structure of PDB entry 1eq0 contains 1 copy of SCOP domain 55084 (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK) in 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. Showing 1 copy in chain A.

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