› 1emo

Solution NMR

NMR STUDY OF A PAIR OF FIBRILLIN CA2+ BINDING EPIDERMAL GROWTH FACTOR-LIKE DOMAINS, 22 STRUCTURES

Released:
DOI: 10.2210/pdb1emo/pdb
PDB 1emo coloured by chain and viewed from the front.
PDB 1emo coloured by chain and viewed from the side.
PDB 1emo coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Solution structure of a pair of calcium-binding epidermal growth factor-like domains: implications for the Marfan syndrome and other genetic disorders.
Downing AK, Knott V, Werner JM, Cardy CM, Campbell ID, Handford PA
Cell 85 597-605 (1996)
PMID: 8653794

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibrillin-1 Chain: A
Molecule details ›
Chain: A
Length: 82 amino acids
Theoretical weight: 8.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35555 (Residues: 2124-2205; Coverage: 3%)
Gene names: FBN, FBN1
Sequence domains: Calcium-binding EGF domain
Structure domains: Laminin

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

52 review citations

Fibrillin microfibrils and elastic fibre proteins: Functional interactions and extracellular regulation of growth factors.
Thomson et al. (2019)
51 more

4 mentions without citation

Microneme proteins in apicomplexans.
Carruthers et al. (2008)
3 more