PDBe 1egw

X-ray diffraction
1.5Å resolution

CRYSTAL STRUCTURE OF MEF2A CORE BOUND TO DNA

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of MEF2A core bound to DNA at 1.5 A resolution.
J. Mol. Biol. 297 437-49 (2000)
PMID: 10715212

Function and Biology Details

Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
MADS BOX TRANSCRIPTION ENHANCER FACTOR 2, POLYPEPTIDE A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 77 amino acids
Theoretical weight: 9.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Transcription factor, MADS-box
DNA (5'-D(*AP*AP*AP*GP*CP*TP*AP*TP*TP*AP*TP*TP*AP*GP*CP*TP*T)-3') Chains: E, H
Molecule details ›
Chains: E, H
Length: 17 nucleotides
Theoretical weight: 5.2 KDa
Source organism: Homo sapiens
Expression system: Not provided
DNA (5'-D(*TP*AP*AP*GP*CP*TP*AP*AP*TP*AP*AP*TP*AP*GP*CP*TP*T)-3') Chains: F, G
Molecule details ›
Chains: F, G
Length: 17 nucleotides
Theoretical weight: 5.21 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF
Spacegroup: P1
Unit cell:
a: 41.371Å b: 60.696Å c: 63.987Å
α: 115.18° β: 89.99° γ: 90°
R-values:
R R work R free
0.206 0.206 0.229
Expression systems:
  • Escherichia coli
  • Not provided