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MECHANISTIC ASPECTS OF CYANOGENESIS FROM ACTIVE SITE MUTANT SER80ALA OF HYDROXYNITRILE LYASE FROM MANIHOT ESCULENTA IN COMPLEX WITH ACETONE CYANOHYDRIN

X-ray diffraction
2.2Å resolution
PDB entry 1e8d coloured by chain, front view.
PDB entry 1e8d coloured by chain, side view.
PDB entry 1e8d coloured by chain, top view.
Source organism: Manihot esculenta
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: (S)-hydroxynitrile lyase
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Multimeric state: homo tetramer
Accessible surface area: 36433.33 Å2
Buried surface area: 7917.96 Å2
Dissociation area: 3,045.36 Å2
Dissociation energy (ΔGdiss): -10.78 kcal/mol
Dissociation entropy (TΔSdiss): 40.22 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-156606

Macromolecules

(S)-hydroxynitrile lyase
Chains: A, B
Length: 262 amino acids
Theoretical weight: 29.82 KDa
Source organism: Manihot esculenta
Expression system: Escherichia coli
UniProt:
  • Canonical: P52705 (Residues: 2-258; Coverage: 100%)
Gene name: HNL
Pfam: alpha/beta hydrolase fold
InterPro:
CATH: alpha/beta hydrolase
SCOP: Hydroxynitrile lyase-like
(S)-hydroxynitrile lyase in PDB entry 1e8d, assembly 1, front view.
(S)-hydroxynitrile lyase in PDB entry 1e8d, assembly 1, side view.
(S)-hydroxynitrile lyase in PDB entry 1e8d, assembly 1, top view.
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