› 1e7g

X-ray diffraction
2.5Å resolution

Human serum albumin complexed with tetradecanoic acid (myristic acid)

Released:
DOI: 10.2210/pdb1e7g/pdb
PDB 1e7g coloured by chain and viewed from the front.
PDB 1e7g coloured by chain and viewed from the side.
PDB 1e7g coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Crystallographic analysis reveals common modes of binding of medium and long-chain fatty acids to human serum albumin.
Bhattacharya AA, Grüne T, Curry S
J. Mol. Biol. 303 721-32 (2000)
PMID: 11061971

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chain: A
Molecule details ›
Chain: A
Length: 585 amino acids
Theoretical weight: 66.57 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P02768 (Residues: 25-609; Coverage: 99%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

1 bound ligand:
Ligand MYR 8 x MYR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: C2
Unit cell:
a: 191.84Å b: 39.02Å c: 95.88Å
α: 90° β: 105.12° γ: 90°
R-values:
R R work R free
0.225 0.225 0.288
Expression system: Saccharomyces cerevisiae

Quick links

Citations

53 review citations

Albumin in decompensated cirrhosis: new concepts and perspectives.
Bernardi et al. (2020)
52 more

10 mentions without citation

High Resolution NMR Spectroscopy as a Structural and Analytical Tool for Unsaturated Lipids in Solution.
Alexandri et al. (2017)
9 more