Structure analysis

Crystal structure of human serum albumin complexed with the general anesthetic halothane

X-ray diffraction
2.38Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 26800 Å2
Buried surface area: 1100 Å2
Dissociation area: 200 Å2
Dissociation energy (ΔGdiss): 5 kcal/mol
Dissociation entropy (TΔSdiss): 2 kcal/mol
Interface energy (ΔGint): -15 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: monomeric
Accessible surface area: 26900 Å2
Buried surface area: 1100 Å2
Dissociation area: 200 Å2
Dissociation energy (ΔGdiss): 2 kcal/mol
Dissociation entropy (TΔSdiss): 2 kcal/mol
Interface energy (ΔGint): -12 kcal/mol
Symmetry number: 1

Macromolecules

Chains: A, B
Length: 585 amino acids
Theoretical weight: 66.57 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P02768 (Residues: 25-609; Coverage: null%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Pfam: Serum albumin family
InterPro:
CATH: Serum Albumin; Chain A, Domain 1
SCOP: Serum albumin-like

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