› 1e7a

X-ray diffraction
2.2Å resolution

Crystal structure of human serum albumin complexed with the general anesthetic propofol

Released:
DOI: 10.2210/pdb1e7a/pdb
PDB 1e7a coloured by chain and viewed from the front.
PDB 1e7a coloured by chain and viewed from the side.
PDB 1e7a coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures.
Bhattacharya AA, Curry S, Franks NP
J. Biol. Chem. 275 38731-8 (2000)
PMID: 10940303

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chains: A, B
Molecule details ›
Chains: A, B
Length: 585 amino acids
Theoretical weight: 66.57 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P02768 (Residues: 25-609; Coverage: 99%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

1 bound ligand:
Ligand PFL 4 x PFL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P1
Unit cell:
a: 55.4Å b: 55.61Å c: 120.5Å
α: 81.11° β: 90.57° γ: 65.5°
R-values:
R R work R free
0.248 0.248 0.272
Expression system: Saccharomyces cerevisiae

Quick links

Citations

28 review citations

Intrinsically Disordered Regions in Serum Albumin: What Are They For?
Litus et al. (2018)
27 more

12 mentions without citation

Heme-based catalytic properties of human serum albumin.
Ascenzi et al. (2015)
11 more