Function and Biology

Structure of isolated FERM domain and first long helix of moesin

Source organism: Homo sapiens
Biochemical function: cytoskeletal protein binding
Biological process: not assigned
Cellular component: cytoskeleton

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF09380
Domain description: FERM C-terminal PH-like domain
Occurring in:
  1. Moesin
1 copy of Pfam domain PF09380 (FERM C-terminal PH-like domain) in Moesin in PDB 1e5w.

PF09379
Domain description: FERM N-terminal domain
Occurring in:
  1. Moesin
1 copy of Pfam domain PF09379 (FERM N-terminal domain) in Moesin in PDB 1e5w.

PF00373
Domain description: FERM central domain
Occurring in:
  1. Moesin
1 copy of Pfam domain PF00373 (FERM central domain) in Moesin in PDB 1e5w.

InterPro InterPro annotations
IPR000798
Domain description: Ezrin/radixin/moesin-like
Occurring in:
  1. Moesin
IPR019749
Domain description: Band 4.1 domain
Occurring in:
  1. Moesin
IPR018980
Domain description: FERM, C-terminal PH-like domain
Occurring in:
  1. Moesin
IPR019748
Domain description: FERM central domain
Occurring in:
  1. Moesin
IPR011993
Domain description: PH-like domain superfamily
Occurring in:
  1. Moesin
IPR018979
Domain description: FERM, N-terminal
Occurring in:
  1. Moesin
IPR014352
Domain description: FERM/acyl-CoA-binding protein superfamily
Occurring in:
  1. Moesin
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Moesin
IPR035963
Domain description: FERM superfamily, second domain
Occurring in:
  1. Moesin
IPR041789
Domain description: ERM family, FERM domain C-lobe
Occurring in:
  1. Moesin

Structure domains

CATH CATH domains
2.30.29.30
Class: Mainly Beta
Architecture: Roll
Topology: PH-domain like
Homology: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Occurring in:
  1. Moesin
1 copy of CATH domain 2.30.29.30 (PH-domain like) in Moesin in PDB 1e5w.
1.20.80.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Acyl-CoA Binding Protein
Homology: Acyl-CoA Binding Protein
Occurring in:
  1. Moesin
1 copy of CATH domain 1.20.80.10 (Acyl-CoA Binding Protein) in Moesin in PDB 1e5w.
1.20.5.450
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Occurring in:
  1. Moesin
1 copy of CATH domain 1.20.5.450 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Moesin in PDB 1e5w.
3.10.20.90
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
  1. Moesin
1 copy of CATH domain 3.10.20.90 (Ubiquitin-like (UB roll)) in Moesin in PDB 1e5w.
SCOP SCOP annotations
50776
Class: All beta proteins
Fold: PH domain-like barrel
Superfamily: PH domain-like
Occurring in:
  1. Moesin
1 copy of SCOP domain 50776 (Third domain of FERM) in Moesin in PDB 1e5w.
47032
Class: All alpha proteins
Fold: Acyl-CoA binding protein-like
Superfamily: Second domain of FERM
Occurring in:
  1. Moesin
1 copy of SCOP domain 47032 (Second domain of FERM) in Moesin in PDB 1e5w.
54256
Class: Alpha and beta proteins (a+b)
Fold: beta-Grasp (ubiquitin-like)
Superfamily: Ubiquitin-like
Occurring in:
  1. Moesin
1 copy of SCOP domain 54256 (First domain of FERM) in Moesin in PDB 1e5w.