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Ternary complex of saccharopine reductase from Magnaporthe grisea, NADPH and saccharopine

Source organism: Pyricularia grisea
Biochemical function: oxidoreductase activity
Biological process: lysine biosynthetic process via aminoadipic acid
Cellular component: cytoplasm

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EC 1.5.1.10: Saccharopine dehydrogenase (NADP(+), L-glutamate-forming)

Reaction catalysed:
N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NADP(+) + H(2)O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH
Systematic name:
N(6)-(L-1,3-dicarboxypropyl)-L-lysine:NADP(+) oxidoreductase (L-glutamate-forming)
Alternative Name(s):
  • 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP(+) oxidoreductase (L-glutamate-forming)
  • Aminoadipate semialdehyde-glutamate reductase
  • Aminoadipic semialdehyde-glutamate reductase
  • Aminoadipic semialdehyde-glutamic reductase
  • Epsilon-N-(L-glutaryl-2)-L-lysine:NAD(+)(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming)
  • Saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase
  • Saccharopine reductase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF16653
Domain description: Saccharopine dehydrogenase C-terminal domain
Occurring in:
  1. Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]
The deposited structure of PDB entry 1e5q contains 8 copies of Pfam domain PF16653 (Saccharopine dehydrogenase C-terminal domain) in Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]. Showing 1 copy in chain A.

PF03435
Domain description: Saccharopine dehydrogenase NADP binding domain
Occurring in:
  1. Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]
The deposited structure of PDB entry 1e5q contains 8 copies of Pfam domain PF03435 (Saccharopine dehydrogenase NADP binding domain) in Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR032095
Domain description: Saccharopine dehydrogenase-like, C-terminal
Occurring in:
  1. Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]
IPR005097
Domain description: Saccharopine dehydrogenase, NADP binding domain
Occurring in:
  1. Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]

Structure domains

CATH CATH domains
3.30.360.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Dihydrodipicolinate Reductase; domain 2
Homology: Dihydrodipicolinate Reductase; domain 2
Occurring in:
  1. Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]
The deposited structure of PDB entry 1e5q contains 8 copies of CATH domain 3.30.360.10 (Dihydrodipicolinate Reductase; domain 2) in Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]. Showing 1 copy in chain A.
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]
The deposited structure of PDB entry 1e5q contains 8 copies of CATH domain 3.40.50.720 (Rossmann fold) in Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]. Showing 1 copy in chain A.
1.10.1870.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Domain 3, Saccharopine reductase
Homology: Domain 3, Saccharopine reductase
Occurring in:
  1. Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]
The deposited structure of PDB entry 1e5q contains 8 copies of CATH domain 1.10.1870.10 (Domain 3, Saccharopine reductase) in Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]. Showing 1 copy in chain A.
SCOP SCOP annotations
51800
Class: Alpha and beta proteins (a/b)
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Occurring in:
  1. Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]
The deposited structure of PDB entry 1e5q contains 8 copies of SCOP domain 51800 (Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain) in Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]. Showing 1 copy in chain A.
55363
Class: Alpha and beta proteins (a+b)
Fold: FwdE/GAPDH domain-like
Superfamily: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
Occurring in:
  1. Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]
The deposited structure of PDB entry 1e5q contains 8 copies of SCOP domain 55363 (Homoserine dehydrogenase-like) in Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]. Showing 1 copy in chain A.

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