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CRYSTAL STRUCTURE OF A CLOSED FORM OF HUMAN MITOCHONDRIAL NAD(P)+-DEPENDENT MALIC ENZYME

X-ray diffraction
2.2Å resolution
PDB entry 1do8 coloured by chain, front view.
PDB entry 1do8 coloured by chain, side view.
PDB entry 1do8 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: NAD-dependent malic enzyme, mitochondrial
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Multimeric state: homo tetramer
Accessible surface area: 76516.81 Å2
Buried surface area: 25646.83 Å2
Dissociation area: 8,047.71 Å2
Dissociation energy (ΔGdiss): 49.24 kcal/mol
Dissociation entropy (TΔSdiss): 47.16 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-149937

Macromolecules

NAD-dependent malic enzyme, mitochondrial
Chains: A, B, C, D
Length: 564 amino acids
Theoretical weight: 63.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P23368 (Residues: 21-584; Coverage: 97%)
Gene name: ME2
Pfam:
InterPro:
CATH:
SCOP:
NAD-dependent malic enzyme, mitochondrial in PDB entry 1do8, assembly 1, front view.
NAD-dependent malic enzyme, mitochondrial in PDB entry 1do8, assembly 1, side view.
NAD-dependent malic enzyme, mitochondrial in PDB entry 1do8, assembly 1, top view.
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