Structure analysis

STRUCTURE OF HIV-1 PROTEASE COMPLEX

X-ray diffraction
2Å resolution
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 8947.25 Å2
Buried surface area: 4766.64 Å2
Dissociation area: 2,054.25 Å2
Dissociation energy (ΔGdiss): 26.06 kcal/mol
Dissociation entropy (TΔSdiss): 11.46 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138017

Macromolecules

Chains: A, B
Length: 99 amino acids
Theoretical weight: 10.77 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P04585 (Residues: 489-587; Coverage: 7%)
Gene name: gag-pol
Pfam: Retroviral aspartyl protease
InterPro:
CATH: Acid Proteases
SCOP: Retroviral protease (retropepsin)

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