› › Function and Biology

CRYSTAL STRUCTURE OF MUTUALLY GENERATED MONOMERS OF DIMERIC PHOSPHORIBOSYLANTRANILATE ISOMERASE FROM THERMOTOGA MARITIMA

Source organism: Thermotoga maritima
Biochemical function: isomerase activity
Biological process: aromatic amino acid family biosynthetic process
Cellular component: not assigned

Quick links

EC 5.3.1.24: Phosphoribosylanthranilate isomerase

Reaction catalysed:
N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
Systematic name:
N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase
Alternative Name(s):
  • IGPS:PRAI (indole-3-glycerol-phosphate synthetase/N-5'-phosphoribosylanthranilate isomerase complex)
  • N-(5'-phosphoribosyl)anthranilate isomerase
  • N-(5-phospho-beta-D-ribosyl)anthranilate ketol-isomerase
  • PRA isomerase
  • PRAI

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00697
Domain description: N-(5'phosphoribosyl)anthranilate (PRA) isomerase
Occurring in:
  1. N-(5'-phosphoribosyl)anthranilate isomerase
The deposited structure of PDB entry 1dl3 contains 2 copies of Pfam domain PF00697 (N-(5'phosphoribosyl)anthranilate (PRA) isomerase) in N-(5'-phosphoribosyl)anthranilate isomerase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001240
Domain description: N-(5'phosphoribosyl) anthranilate isomerase (PRAI) domain
Occurring in:
  1. N-(5'-phosphoribosyl)anthranilate isomerase
IPR044643
Domain description: N-(5'-phosphoribosyl)anthranilate isomerase family
Occurring in:
  1. N-(5'-phosphoribosyl)anthranilate isomerase
IPR011060
Domain description: Ribulose-phosphate binding barrel
Occurring in:
  1. N-(5'-phosphoribosyl)anthranilate isomerase
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. N-(5'-phosphoribosyl)anthranilate isomerase

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. N-(5'-phosphoribosyl)anthranilate isomerase
The deposited structure of PDB entry 1dl3 contains 2 copies of CATH domain 3.20.20.70 (TIM Barrel) in N-(5'-phosphoribosyl)anthranilate isomerase. Showing 1 copy in chain B.
SCOP SCOP annotation
51381
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: Ribulose-phoshate binding barrel
Occurring in:
  1. N-(5'-phosphoribosyl)anthranilate isomerase
The deposited structure of PDB entry 1dl3 contains 2 copies of SCOP domain 51381 (Tryptophan biosynthesis enzymes) in N-(5'-phosphoribosyl)anthranilate isomerase. Showing 1 copy in chain B.

Quick links